Functional characterization of the kidneys of preterm infants born to mothers with preeclampsia
Abstract
The aim of the study was to identify kidney dysfunction in infants born prematurely to mothers with preeclampsia. Forty-eight preterm infants, including 15 babies born to mothers with preeclampsia (a study group), 13 neonates whose mothers had complicated pregnancy without preeclampsia (a comparison group), and 15 apparently healthy infants (a control group) were examined. To evaluate renal tubular function, the indicators, namely: kidney injury molecule-1 (ЮМ-1) and neutrophil gelatmase-associated lipokalin-2 (NGAL) were determined on 1—3 and 7—10 days of their life. Glomerular filtration rate was estimated to assess the performance of the glomerular apparatus. The study group was found to have the high values of tubular injury markers on 1 to 7—10 days of life, which significantly differed from those in the control and comparison groups (/КО,05). The glomerular filtration rate reflecting the capacity of the glomerular apparatus in the infants born to preeclamptic mothers was lower than that in the control group, but similar to that in the comparison group with a tendency towards normalization by the end of the early neonatal period. Thus, glomerular injury was short-term and abolished during adequate therapy whereas the high urinary levels of KJM-1 and NGAL from the first to 10th days of life confirm persistent tubular injury in the infants born to preeclamptic mothers.
About the Authors
N. F. Panakhova
Azerbaijan Medical University, Baku
Azerbaijan
Azerbaijan
S. Sh. Gasanov
Azerbaijan Medical University, Baku
Azerbaijan
Azerbaijan
A. A. Akhundova
Azerbaijan Medical University, Baku
Azerbaijan
Azerbaijan
S. M. Aleskerova
Azerbaijan Medical University, Baku
Azerbaijan
Azerbaijan
A. A. Polukhova
Azerbaijan Medical University, Baku
Azerbaijan
Azerbaijan
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Review
For citations:
Panakhova N.F., Gasanov S.Sh., Akhundova A.A., Aleskerova S.M., Polukhova A.A. Functional characterization of the kidneys of preterm infants born to mothers with preeclampsia. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2014;59(3):57-62. (In Russ.)
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