Combination treatment for ventilator-associated pneumonia in neonatal infants
https://doi.org/10.21508/1027-4065-2016-61-2-92-99
Abstract
The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants.
About the Authors
M. V. Kushnareva
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. Yu. Gerasimov
Maternal Hospital Fifteen, City Clinical Hospital Thirteen
Russian Federation
Moscow
Russian Federation
Moscow
G. M. Dementieva
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. S. Keshishian
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
T. S. Okuneva
Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Kushnareva M.V., Gerasimov A.Yu., Dementieva G.M., Keshishian E.S., Okuneva T.S. Combination treatment for ventilator-associated pneumonia in neonatal infants. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(2):92-99. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-2-92-99
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