Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis
https://doi.org/10.21508/1027-4065-2016-61-4-104-107
Abstract
Molecular allergy diagnosis makes it possible not only to identify allergic sensitization to peanut as a whole, but also to establish the specific allergen the specific IgE is synthesized to. The purpose of this study was to establish a relationship between sensitization to certain molecules of peanut and allergy as anaphylaxis after eating the product. An immunofluorescence assay (Immuno CAP 100 Phadia AB, Switzerland) was used to determine specific IgE to whole allergen in the peanut and its components (Ara h1, Ara h2, Ara h3, Ara h8, and h9 Ara). Children diagnosed with peanut-induced anaphylaxis were found to be significantly more sensitized to the recombinant allergens Ara h8 and Ara h9 (p=0.019). The detected combination of sensitization to the recombinant peanut allergen Ara h8 and Ara h9 indicates a high probability that an allergic reaction may manifest as anaphylaxis. Determination of specific IgE against peanut proteins will optimize patient management tactics.
About the Authors
A. M. Shulyaeva
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow
Russian Federation
Russian Federation
A. N. Pampura
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow
Russian Federation
Russian Federation
T. S. Okuneva
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Shulyaeva A.M., Pampura A.N., Okuneva T.S. Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(4):104-107. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-4-104-107
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