Sensitization to allergens of domestic animals
https://doi.org/10.21508/1027-4065-2018-63-2-22-26
Abstract
At present, sensitization to airborne allergens in domestic animals is absolutely rightly considered one of the key risk factors for the development of allergic rhinitis and bronchial asthma, as well as largely determines the development of severe forms of atopic dermatitis and respiratory allergosis. Of particularimportance isthe fact that, unlike othertriggers, the elimination of allergensin domestic animals is often associated with internal resistance from patients. The article presents the current data on the prevalence of sensitization, the properties and clinical significance of the main allergens of cats and dogs, outlines approaches to conducting elimination activities.
About the Authors
A. N. PampuraRussian Federation
E. E. Varlamov
Russian Federation
N. G. Konyukova
Russian Federation
References
1. Pyrhönen K., Näyhä S., Läärä E. Dog and cat exposure and respective pet allergy in early childhood. Pediatr Allergy Immunol 2015; 26(3): 247–255. DOI: 10.1111/pai.12369
2. Asarnoj A., Hamsten C., Wadén K., Lupinek C., Andersson N., Kull I. et al. Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study. J Allergy Clin Immunol 2016; 137(3): 813–821. DOI: 10.1016/j. jaci.2015.09.052
3. Konradsen J.R., Fujisawa T., van Hage M., Hedlin G., Hilger C., Kleine-Tebbe J. et al. Allergy to furry animals: New insights, diagnostic approaches, and challenges. J Allergy Clin Immunol 2015; 135(3): 616–625. DOI: 10.1016/j. jaci.2014.08.026
4. Emara M., Royer P.J., Abbas Z., Sewell H.F., Mohamed G.G., Singh S. et al. Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity. J Biol Chem 2011; 286: 13033– 13040. DOI: 10.1074/jbc.M111.220657
5. Ihuoma H., Belgrave D.C., Murray C.S., Foden P., Simpson A., Custovic A. Cat ownership, cat allergen exposure, and trajectories of sensitization and asthma throughout childhood. J Allergy Clin Immunol 2017; 28: S0091–6749(17)31653-6. DOI: 10.1016/j.jaci.2017.09.030
6. Liccardi G., Bilò M.B., Manzi F., Piccolo A., Di Maro E., Salzillo A. What could be the role of molecular-based allergy diagnostics in detecting the risk of developing allergic sensitization to furry animals? Eur Ann Allergy Clin Immunol 2015; 47(5): 163–167.
7. Gergen P.J., Elliott L., Zeldin D.C. Prevalences of positive skin test response to 10 common allergens in the US population: results from the third national health and nutrition examination survey. J Allergy Clin Immunol 2005; 116: 377–383. DOI: 10.1016/j.jaci.2005.05.017
8. Arbes S.J., Basak P., Arayata R., Brensilver J. Prevalence of specific aeroallergen sensitivity on skin prick test in patients with allergic rhinitis in Westchester County. The Internet Journal of Asthma, Allergy and Immunology 2008; 6: 2.
9. Gruchalla R.S., Pougracic J., Plant M., Evans R., Visness C.M., Walter M. et al. Inner City Asthma Study: Relationship among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol 2005; 115: 478–485. DOI: 10.1016/j.jaci.2004.12.006
10. Haftenberger M., Laußmann D., Ellert U., Kalcklösch M., Lan-gen U. et al. Prevalence of sensitisation to aeroallergens and food llergens: results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2013; 56: 687–697. DOI: 10.1007/s00103-012-1658-1
11. Wickmann M., Asarnoj A., Tillander H., Andersson N., Berg-ström A., Kull I. et al. Childhood-toadolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort. J Allergy Clin Immunol 2014; 133: 580–582. DOI: 10.1016/j.jaci.2013.09.009
12. Svanes C., Heinrich J., Jarvis D., Chinn S., Omenaas E., Gulsvik A. et al. Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. J Allergy Clin Immunol 2003; 112: 289–300. DOI: 10.1067/ mai.2003.1596
13. Custovic A., Hallam C.L., Simpson B.M., Craven M., Simp-son A., Woodcock A. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol 2001; 108: 537–539. DOI: 10.1067/mai.2001.118599
14. Konradsen J.R., Nordlund B., Onell A., Borres M.P., Gronlund H., Hedlin G. Severe childhood asthma and allergy to furry animals: Refined assessment using molecular-based allergy diagnostics. Pediatr Allergy Immunol 2014; 25: 187– 192. DOI: 10.1111/pai.12198
15. Bjerg A., Winberg A., Berthold M., Mattsson L., Borres M.P., Rönmark E. A population based study of animal component sensitization, asthma, and rhinitis in schoolchildren. Pediatr Allergy Immunol 2015; 26: 557–563. DOI: 10.1111/ pai.12422
16. Almqvist C., Wickman M., Perfetti L., Berglind N., Renstrom A., Hedren M. et al. Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. Am J Respir Crit Care Med 2001; 163: 694-698. DOI: 10.1164/ ajrccm.163.3.2006114
17. Perfetti L., Hebert J., Lapalme Y., Ghezzo H., Gautrin D., Malo J.L. Changes in IgE-mediated allergy to ubiquitous inhalants after removal from or diminution of exposure to the agent causing occupational asthma. Clin Exp Allergy 1998; 28: 66–73. DOI: 10.1046/j.1365-2222.1998.00193.x
18. Moral de Gregorio A., Carretero Aníbarro P., Mateo Borrega M., Zapata Yébenes J. Principales alérgenos de interior. Tratado de Alergología. 2a ed. Tomo I. Madrid: Ergón, 2015; 287–310.
19. Vredegoor D.W., Willemse T., Chapman M.D., Heederik D.J., Krop E.J. Can f 1 levels in hair and homes of different dog breeds: lack of evidence to describe any dog breed as hypoallergenic. J Allergy Clin Immunol 2012; 130(4): 904–909. DOI: 10.1016/j.jaci.2012.05.013
20. Butt A., Rashid D., Lockey R.F. Do hypoallergenic cats and dogs exist? childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics. Ann Allergy Asthma 2012; 108(2): 74–76. DOI: 10.1016/j. anai.2011.12.005
21. Virtanen T. Immunotherapy for pet allergies. Hum Vaccin Immunother 2017; 28: 1–8. DOI: 10.1080/21645515.2017.1409315
Review
For citations:
Pampura A.N., Varlamov E.E., Konyukova N.G. Sensitization to allergens of domestic animals. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(2):22-26. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-2-22-26