EARLY DIAGNOSIS OF CARNITINE INSUFFICIENCY IN PREMATURE INFANTS
https://doi.org/10.21508/1027-4065-2018-63-3-39-44
Abstract
The authors present their finding from the examination of 45 premature babies depending on the gestational age. A general clinical examination and study of free and acylated carnitine levels in blood were performed. Nonspecific clinical signs of carnitine deficiency in premature infants have been established. The study of carnitine metabolism revealed the dependence of the studied parameters on the gestational age of premature infants.
About the Authors
U. F. Nasirova
Tashkent Institute of Postgraduate Medical Education
Uzbekistan
Uzbekistan
R. M. Tastanova
Tashkent Pediatric Medical Institute
Uzbekistan
Uzbekistan
A. A. Pak
Republican Center “Mother and Child Screening”
Uzbekistan
Uzbekistan
Tashkent
M. K. Sharipova
Republican Center “Mother and Child Screening”
Uzbekistan
Uzbekistan
Tashkent
References
1. Sukhorukov V.S., Nikolaeva E.A.(ed) Cellular energy metabolic disturbances in children. Moscow: Ates Medica Soft 2004; 79. (in Russ)
2. Gorban’ T.S., Degtyareva M.V., Babak O.A., Vorontsova Yu.N., Zakharova E.Yu., Baydakova G.V. et al. Dynamics of carnitine concentrations in blood serum in infants with very low birth weight. Vopr praktich pediatr (Clinical Practice in Pediatrics) 2011; 3: 14–18. (in Russ)
3. Garmaeva V.V. The fetal and neonatal features of the biosynthesis, metabolism, and function of carnitine. Ros vestn perinatol i pediatr 2007; 5: 21–26. (in Russ)
4. Alyamovskaya G.A., Zolkina I.V., Keshishian E.S. Secondary carnitine deficiency in low birth weight (less than 1500 g) premature infants in the pathogenesis of energy deficiency during their first-second years of life and possibilities of its correction. Ros vestn perinatol i pediatr 2012; 4 (2): 126–131. (in Russ)
5. Brin I.L., Elkar (20% solution of L-carnitine) in pediatrics. Scientific review. Moscow 2005; 36. (in Russ)
6. Koumantakis E., Sifakis S., Koumantaki Y., Hassan E., Matalliotakis I., Papadopoulou E. et al. Plasma carnitine levels of pregnant adolescents in labor. J Pediat Adolesc Gynecol 2001; 14: 65–69.
7. O’Donnell J., Finer N.N., Rich W., Barshop B.A., Barrington K.J. Role of L-carnitine in apnea of prematurity: a randomized, controlled trial. Pediatrics 2002; 109: 4: 622–626.
8. Sweetman L., Ashcraft Р. Newborn screening by tandem mass spectrometry: gaining experience. Clinical chemistry 2001; 47: 11: 1937–1938.
9. Nikolaeva E.A., Zolkina I.V., Kharabadze M.N. Correction of carnitine deficiency in children with mitochondrial diseases. Praktika pediatra 2011; October: 44–48. (in Russ)
10. Chace D.H., Pons R., Chiriboga C.A., Mcmahon D.J., Tein I., Naylor E.W. et al. Neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectrometry. Pediatric Research 2003; 53: 5: 823–829.
11. Gucciardi A., Zaramella P., Costa I., Pirillo P., Nardo D., Naturale M. et al. Analysis and interpretation of acylcarnitine profiles in dried blood spot and plasma of preterm and full-term newborns. Pediatric Research 2015; 77: 1: 36–47. DOI:10.1038/pr.2014.142
12. Meyburg J., Schulze A., Kohlmueller D., Poschl J., Linder- kamp O., Hoffmann G.F.et al. Acylcarnitine profiles of preterm infants over the first four weeks of life. Pediatric Res 2002; 52: 5: 720–723.
Review
For citations:
Nasirova U.F., Tastanova R.M., Pak A.A., Sharipova M.K. EARLY DIAGNOSIS OF CARNITINE INSUFFICIENCY IN PREMATURE INFANTS. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(3):39-44. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-3-39-44
Views:
1365
Email this article 