Preview

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

Advanced search

EXPERIENCE OF CYCLOFERON THERAPY IN THE COMPLEX THERAPY OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN

https://doi.org/10.21508/1027-4065-2018-63-3-98-104

Abstract

The article contains materials on the use of antiviral and immune stimulating drugs for treatment of infectious processes of viral aetiology. The potential of using Cycloferon in children with recurrent infections are shown. Prescription of nonspecific immune modulators of the topical (derinat) and systemic (cycloferon) effect as etiotropic and immune modulating therapy for sickly children was justified from the pathogenetical point of view. The findings of our studies on the efficacy of the latter in children with different states of the  pharyngeal lymphoid ring and complicated course of acute respiratory infection are presented. It is shown that the frequency of acute  respiratory infections in children depends on the child’s age, immune status, and not on the state of the pharyngeal lymphoid ring.

About the Authors

L. A. Kharitonova
Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Russian Federation

Moscow



O. E. Israfilova
Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Russian Federation

Moscow



References

1. Pokrovskiy V.I., Lvov D.K., Kiselev O.I., Ershov F.I. Influenza and influenza-like infections, including particularly dangerous forms of influenza infection. Fundamental and applied aspects of the studying: Bulletin of the task group. St. Petersburg: Rosa Mira, 2008; 109. (in Russ).

2. Zaplatnikov A.A., Girina I.V., Lepiseva N.S., Glukhareva N.S. Recurrent respiratory infections in children: modern possibilities of immunoprophylaxis. Praktika Pediatra 2013; 2: 50–54. (in Russ)

3. Ershov F.I., Romantsov M.G. Medicinal products used in viral diseases: Guide for physicians. Мoscow: GEOTAR-Media 2007; 368. (in Russ)

4. Ершов Ф.И., Новохватский А.С. Интерферон и его индукторы. М: Медицина 1996; 240 [Ershov F.I., Novokhvatskij A.S. Interferon and its inducers. Мoscow: Meditsina 1996; 240]

5. Vial T., Choquet-Kastylevsky G., Liautard C., Descotes J. Endocrine and neurological adverse effects of the therapeutic interferons. Toxicology 2000; 142: 161–172.

6. Tran T.D., Pryde D.C., Jones P., Adam F.M., Benson N., Bish G. et al. Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection. Bioorg Med Chem Lett 2011; 21: 2389–2393. DOI: 10.1016/j.bmcl.2011.02.092

7. Sokolova T.M., Uryvaev L.V., Tazulahova Je.B., Ershov F.I., Mal’shenkova I.K., Didkovskij I.K., Didkovskij N.A. Individual changes in the expression of the interferon genes in human blood cells under the influence of Amixin and Сycloferon. Problems of virology 2005; 2: 32–36. (in Russ)

8. Zohari S., Munir M., Metreveli G., Belak S., Berg M. Differences in the ability to suppress interferon beta production between allele A and allele B NS1 proteins from H10 infl uenza A viruses. Virology J 2010; 7 (1): 376.

9. Romantsov M.G. The use of Cycloferon in pediatric practice. Guidance manual. St. Petersburg 2000; 100. (in Russ)

10. Kovalenko A.L., Alekseeva L. E. Cycloferon in clinical practice. St. Petersburg 2000; 17–19. (in Russ)

11. Romantsov M.G., Melnikova I.Yu., Smagina A.H., Shuldyakov A.A. The effectiveness of Cycloferon and evaluation of its safety in respiratory viral infections in children. Fundamental research (Fundamental’nye issledovaniya) 2012; 2: 208–214. (in Russ)

12. Ershov F.I., Kovalenko A.L., Romantsov M.G., Golubev S.Yu. Cycloferon. Clinical pharmacology and therapy. Guide for physicians. St. Petersburg 1998; 109. (in Russ)

13. Romantsov M.G., Sologub T.V., Petrov A.Yu., Kovalenko A.L. Cycloferon in the treatment and emergency prevention of respiratory viral infections and influenza. Retsept 2011; 6: 59–65. (in Russ)

14. Didkovskij N.А., Narovlyanskij A.N., Kovalenko A.L. Cycloferon in clinical practice. St. Petersburg 2000; 20. (in Russ).

15. The efficacy of Derinat in the treatment of chronic adenoiditis in children. A.R. Mangushev, V.V. Rafailov. Vestnik Oto-Rino-Laringol (Annals of ENT) 2008; 6: 33–34. (in Russ)

16. Kuselman A.I. Clinical efficacy of Derinat in pediatric practice. Terra Medica nova 2006; 3: 21–25. (in Russ)


Review

For citations:


Kharitonova L.A., Israfilova O.E. EXPERIENCE OF CYCLOFERON THERAPY IN THE COMPLEX THERAPY OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(3):98-104. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-3-98-104

Views: 991


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1027-4065 (Print)
ISSN 2500-2228 (Online)