CLINICAL SIGNIFICANCE OF DETERMINATION OF IGE ANTIBODIES TO STAPHYLOCOCCUS AUREUS AND MALASSEZIA SPECIES IN SERUM OF CHILDREN WITH ATOPIC DERMATITIS
https://doi.org/10.21508/1027-4065-2018-63-4-84-88
Abstract
We studied the frequency of occurrence and concentration of allergen-specific IgE antibodies (asIgE) to enterotoxins A, B, C and TSST-1 of Staphylococcus aureus and Malassezia spp. in the serum of children with atopic dermatitis in the acute period of the disease. The determination of asIgE levels was performed in 84 children aged from 5 months to 17 years using the immunochemiluminescent method on the UniCAP 100 analyzer (Phadia, Sweden). The level of asIgE was evaluated on a scale of 6 classes.
The sensitization to S. aureus enterotoxins was detected in 29 children with аsIgE concentration from 0.35 to 25.8 kU/L (I–IV classes). In 16 children were observed 8 polysensitization options to S. aureus allergens. Combinations of asIgE to A + B and A + B + C enterotoxins were most common – in every fourth and fifth child,respectively. Sensitization to Malassezia spp. was observed in 41 children with concentration from 0.38 to 98.9 KU/L (I–V classes). Polysensitization to both S. aureus and Malassezia spp. allergens was observed in one of two children. A higher degree of sensitisation to Malassezia spp allergens has been established compared to S. aureus.
Conclusion. To improve the specific diagnostics of atopic dermatitis, it is advisable to examine the serum for a complete panel of recombinant S. aureus enterotoxins in combination with the determination of asIgE to Malassezia spp.
About the Authors
T. S. Okuneva
Scientific Research Clinical Institute of Pediatrics named after Academician Yu.E.Veltishchev of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
M. V. Kushnareva
Scientific Research Clinical Institute of Pediatrics named after Academician Yu.E.Veltishchev of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
A. N. Pampura
Scientific Research Clinical Institute of Pediatrics named after Academician Yu.E.Veltishchev of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
E. E. Varlamov
Scientific Research Clinical Institute of Pediatrics named after Academician Yu.E.Veltishchev of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
N. G. Konyukova
Scientific Research Clinical Institute of Pediatrics named after Academician Yu.E.Veltishchev of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Okuneva T.S., Kushnareva M.V., Pampura A.N., Varlamov E.E., Konyukova N.G. CLINICAL SIGNIFICANCE OF DETERMINATION OF IGE ANTIBODIES TO STAPHYLOCOCCUS AUREUS AND MALASSEZIA SPECIES IN SERUM OF CHILDREN WITH ATOPIC DERMATITIS. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2018;63(4):84-88. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-4-84-88
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