Connective tissue dysplasia-associated cardiac pathology in women and their newborns
Abstract
Connective tissue dysplasia is the constitutional basis for cardiac pathology in women and their newborn infants. A higher serum free hydroxyproline concentration and a lower free to peptide-bound hydroxyproline ratio in women with congenital heart disease in the presence of connective tissue dysplasia and a similar trend of changes in these markers in their newborns diagnosed with congenital atrial septal defect indicate the slowed metabolism of collagen and its reduced biological recycling rate, which serves as a poor prognostic sign. The mentioned biochemical markers may be used as additional criteria for preclinical diagnosis of fetal and neonatal cardiac diseases, for assessment of their prognosis and for implementation of preventive measures.
About the Authors
R. R. Kildiyarova
Izhevsk State Medical Academy
Russian Federation
Russian Federation
D. F. Uglova
Republican Clinical and Diagnostic Center, Izhevsk
Russian Federation
Russian Federation
References
1. Арсентьев В.Г. Дисплазии соединительной ткани как конституциональная основа полиорганных нарушений у детей: Автореф. дис. … д-ра мед. наук. Ст-Петербург 2013; 40. (Arsentev V.G. Connective tissue dysplasia as the constitutional basis of multiple organ disorders in children: Avtoref. dis. ... d-ra med. nauk. St-Petersburg 2013; 40.)
2. Кадурина Т.И., Гнусаев С.Ф., Земцовский Э.В. и др. Наследственные и многофакторные нарушения соединительной ткани у детей. Алгоритмы диагностики, тактика ведения. Синдром соединительнотканной дисплазии у детей. Российские рекомендации. Педиатрия 2014; 93: 5 (приложение): 1—40. (Kadurinа T.I., Gnusaev S.F., Zemtsovsky E.V. et al. Hereditary and multifactor connective tissue disorders in children. Diagnostic algorithms, tactics. Syndrome connective tissue disorders in children. Russian recommendations. Pediatriya 2014; 93: 5 (suppl): 1—40.)
3. Стрелков Н.С., Кильдиярова Р.Р., Шараев П.Н., Ишмаметьев И.Л. Соединительная ткань у детей при патологии. Под ред. Р.Р. Кильдияровой. Ижевск 2011; 210. (Strelkov N.S., Kildiyarova R.R., Sharaev P.N., Ishmametev I.L. Connective tissue disease in children. R.R. Kildiyarovа (ed.). Izhevsk 2011; 210.)
4. Углова Д.Ф. Перинатальные исходы у беременных с врожденными пороками сердца на фоне соединительнотканной дисплазии: Автореф. дисс. … канд. мед. наук. Волгоград 2013; 24. (Uglova D.F. Perinatal outcomes in pregnant women with congenital heart disease on the background of connective tissue dysplasia: Avtoref. dis. ... kand. med. nauk. Volgograd 2013; 24.)
5. Byers P.H., Pyeritz R.E. Research perspectives in heritable disorders of connective tissue. J Matrix 1992; 12: 4: 333—342.
Review
For citations:
Kildiyarova R.R., Uglova D.F. Connective tissue dysplasia-associated cardiac pathology in women and their newborns. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2015;60(2):54-56. (In Russ.)
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