Преэклампсия матери и программирование сердечно-сосудистого здоровья ребенка
https://doi.org/10.21508/1027-4065-2019-64-4-19-25
Аннотация
Представлен обзор литературы, посвященной проблеме программирования формирования структуры и функции сердечнососудистой системы у детей от матерей с преэклампсией. Такие дети имеют высокий риск развития сердечно-сосудистых заболеваний в последующей жизни. Показано, что в основе развития преэклампсии лежат дисфункция эндотелия, нарушения регуляции иммунных и воспалительных факторов при беременности. Экспериментальные исследования идентифицируют эти факторы как ключевые эпигенетические факторы программирования состояния сердечно-сосудистой системы потомства. Современная концепция внутриутробного программирования, описывающая этот феномен, сфокусирована на трех основных областях исследований: экспериментальных моделях, имитирующих внутриутробную среду при преэклампсии; изучении того, как у человека формируется патологический фенотип под влиянием указанных факторов; эпигенетических исследованиях воздействия преэклампсии на функцию сердечно-сосудистой системы. Обсуждаются перспективы профилактики эпигенетического программирования.
Об авторах
О. П. Ковтун
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
Россия
Россия
д.м.н., проф., чл.- корр. РАН, ректор,
Екатеринбург
П. Б. Цывьян
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России;
ФГБУ «Уральский научно-исследовательский институт охраны материнства и младенчества» Минздрава России
Россия
Россия
д.м.н., проф., зав. кафедрой нормальной физиологии;
вед. науч. сотр.,
620028 Екатеринбург, ул. Репина, д. 3
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Рецензия
Для цитирования:
Ковтун О.П., Цывьян П.Б. Преэклампсия матери и программирование сердечно-сосудистого здоровья ребенка. Российский вестник перинатологии и педиатрии. 2019;64(4):19-25. https://doi.org/10.21508/1027-4065-2019-64-4-19-25
For citation:
Kovtun O.P., Tsyvian P.B. Pre-eclampsia in a mother and programming of the child’s cardiovascular health. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(4):19-25. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-4-19-25
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