Pre-eclampsia in a mother and programming of the child’s cardiovascular health
https://doi.org/10.21508/1027-4065-2019-64-4-19-25
Abstract
The authors present a review of the literature devoted to the problem of programming the formation of the cardiovascular system structure and function in children born from mothers with preeclampsia. These children are at high risk of developing cardiovascular diseases. Pre-eclampsia is caused by the endothelium dysfunction, deregulation of the immune and inflammatory factors during pregnancy. Experimental studies identify these factors as key epigenetic factors programming the condition of the cardiovascular system of the offspring. The modern concept of intrauterine programming, describing this phenomenon, focuses on three main areas of research: experimental models simulating the intrauterine environment with preeclampsia; research of the pathological phenotype formation under the influence of these factors; epigenetic studies of the influence of preeclampsia on the cardiovascular system functioning. The article discusses the perspectives of epigenetic programming prevention.
About the Authors
O. P. Kovtun
Ural State Medical University
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
P. B. Tsyvian
Ural State Medical University;
Mother and Child Care Research Institute
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
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Review
For citations:
Kovtun O.P., Tsyvian P.B. Pre-eclampsia in a mother and programming of the child’s cardiovascular health. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(4):19-25. (In Russ.) https://doi.org/10.21508/1027-4065-2019-64-4-19-25
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