Gender-related clinical and immunological features of extremely low birth weight infants
https://doi.org/10.21508/1027-4065-2016-61-5-24-29
Abstract
Examinations were made in 35 boys and 39 girls with extremely low birth weight in order to identify gender-related clinical and immunological features. A comparison group consisted of 31 full-term newborns with early uncomplicated adaptation. The investigators determined the number of lymphocyte subpopulations and cytokine-producing cells (CD3+INF-γ+, CD3+IL-4+) by flow cytometry and the serum levels of cytokines (IL-4, IFN-γ) and neopterin by enzyme immunoassay. A study of immunological parameters revealed that the boys had a smaller number of CD3+, CD4+, and CD8+ subpopulations, a reduced content of CD3+IL-4+ cells at birth, and low IL-4 production on the first day of life compared to the full-term neonates. The girls were recorded to have higher levels of neopterin and B cells on the first day of life, the quantitative characteristics of T lymphocytes were consistent with those in the full-term infants. The findings are indicative of the greater functional immaturity of the immune system in the preterm boys.
About the Authors
G. N. Chistyakova
Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg
Russian Federation
Russian Federation
L. S. Ustyantseva
Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg
Russian Federation
Russian Federation
I. I. Remizova
Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg
Russian Federation
Russian Federation
V. A. Lyapunov
Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg
Russian Federation
Russian Federation
I. A. Gazieva
Ural Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation, Yekaterinburg
Russian Federation
Russian Federation
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Review
For citations:
Chistyakova G.N., Ustyantseva L.S., Remizova I.I., Lyapunov V.A., Gazieva I.A. Gender-related clinical and immunological features of extremely low birth weight infants. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2016;61(5):24-29. (In Russ.) https://doi.org/10.21508/1027-4065-2016-61-5-24-29
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